Study on ASCUS

            Results

            18 out of the presented population of 227 individuals were established to have ASCUS from the histological follow-up. This is identified as abnormal Pap smears reading.  The population was therefore represented by 18% of the total population. In regard to the occurrence of the ASCUS reading the population is, therefore, high in the general group of the presented women.

            The total number of collected results was 227 from women in perimenopausal as well as postmenopausal categories which were 107 and 120 respectively.  The mean ages were 46 in the general population utilized in the study. The abnormal cells determined occupied a population of 18% with the remaining percentage of diagnoses being glandular typical cells which were of undetermined importance.

            Discussion

            The diagnostic kind of ASCUS cells differs in verse and the importance among the individual pathologists as well as among the laboratories of cytology. The rate of subsequent and concurrent squamous lesions intraepithelial in women with ASCUS found on the Pap smear investigation, therefore, illustrates a wide literature range. The importance of postmenopausal and premenopausal women is currently unclear based on the results of this study (Fan, & Damjanov, 2012).  The study, therefore, made the conclusions based on the comparison of results based on ASCUS and SIL diagnoses.  The results were therefore derived from postmenopausal, premenopausal as well as premenopausal women above the ages of forty-five years.

            The pathologist’s referred to the cells as ASCUS because of the associated abnormality of the acquired results which were derived from the Pap smear tests. ASCUS is common although it is not a normal test for Pap the results of the Pap, therefore, indicates cells that are typical and are of undermined importance. This is therefore considered as an irregular reading (Fan, & Damjanov, 2012). This is the main reason why the pathologists called the cells found in the women ASCUS.  The HPV testing of the women was followed up by the standard care.  The results of the women indicated that they were ASCUS positive and negative for HPV high-risk strains. This was followed by the repeat of pap testing in order to fully watch the response of the immune in order to effectively resolve the abnormal cells. The results therefore did not require the women to take colonoscopy diagnosis since they did not showed signs of HPV high risk strains (Fan, & Damjanov, 2012).

            The results of this research, therefore, indicate that abnormal rate reduces with the increase in age of women for SIL as opposed to the ASCUS. Women between 45 to 50 years were established to hold greater capability rate of ASCUS. This has been shown by other authors who indicate lowered rate of abnormality in older women. The pathologist, therefore, referred to the endometrial cells as ASCUS because of the abnormality of the results. In addition, the results did not indicate the existence of HPV strains which thus showed that they had ASCUS (Fan, & Damjanov, 2012). This, therefore, differs from researchers because they hold that the occurrence of ASCUS readings is very irregular. This is because the researchers hold that the endometrial cells presence after the12th day after the menstrual cycle has occurred is normal and it should not, therefore, be considered as ASCUS (Fan, & Damjanov, 2012). Based on the findings of different authors ASCUS abnormalities in perimenopausal women is important in carrying out the actual risk of the underlying lesion intraepithelial.

            Conclusion

            It is clear that endometrial cells are reported in women who are above the age of 40 years.  This is because age is available more consistently than in the status of menopause. Despite the decreased rate of abnormality with the age increase, the current study findings established that postmenopausal and premenopausal women groups have more elevated ASCUS  RATIOS AS COMPARED TO SIL. ASCUS therefore appears to have particularly high positive prediction worth for SIL in women who are premenopausal and therefore they are more likely to be overcalled in the women who are more than 45 years of age.

            Recommendation

            The study therefore suggests that pathologists should be aware of changes that are related to different ages in order to make adequate adjustments with regard to the criteria of diagnoses. This may also require an over adjustment because of ASCUS PPV which appears to be increasing in women above the age of 45 years. The information therefore is relevant because it can be used in subtle heterophobic and air drying pieces as well as changes.  The information is, therefore, relevant in allowing individuals researchers to identify areas which should be improved to prevent the occurrence of ASCUS abnormality in premenopausal women with age increase. The findings, therefore, indicate that there is a need to research on the potential of ASCUS in women who are beyond the ages of 45 years. This is to provide knowledge to the existing literature which holds the occurrence of ASCUS with the negative indication of HPV high-risk strain as abnormal.  This will help in developing prevention measures as well as more equipped strategies of diagnoses.

 

References

Fan, F., & Damjanov, I. (2012). Cytopathology review.