Assignment , summaries of sources cse style. Which drugs are the best for adjuvant chemotherapy and why

In adjuvant or neoadjuvant treatment, chemo drugs are the most helpful drug that works best when it is combined with other drugs such as Taxanes, 5-fluorouracil and carboplatin. Among the many drugs that can treat adjuvant chemotherapy, the three are the best (Summerhayes, 2002). There are several cancer complications that include breast cancer and ESCC that are addressed in various articles that detail these drugs. This paper will provide a summary of why Taxanes, 5-fluorouracil and carboplatin are the best drugs in treating the adjuvant chemotherapy (Summerhayes, 2002).

5-Fluorouracil drug is the best in curing esophageal squamous cell carcinoma (ESCC).  ESCC is a very deadly disease that is best handled through the chemotherapy strategy. 5-Fluorouracil is a key and first line drug against ESCC. It is very efficient considering is content of anabolic and catabolic that exert cytotoxicity. The drug enters the process of anabolic that triggers the normal function of the nuclei enzymes and acids that work as the healing process. The 5-FU drug is best because it is resistant to ESCC cells. The resistance fastens the healing process and enhances its effectiveness.

Carboplatin is another chemotherapy drug that is best in curing testicular cancer. It has proven to be a cure to many other malignancies among them being testicular cancer. The efficiency of carboplatin is the total drug exposure (Osamue et al, 2015). This is a function that determines the dose as well as clearance. The carboplatin has a narrow range of exposure as well as therapeutic range which remain to the stronghold of the drug efficiency (Osamue et al, 2015). The drug has very minimal toxic which is an advantage that maintains a patient in a toxic free condition hence affecting the efficiency of the healing process. A statistical summary shows that 9.6% of the carboplatin done was used to treat 50% of cancer patients hence proving its efficiency (Osamue et al, 2015).

Taxanes are the best in curing breast cancer with significant recovery of cancer patients. Breast cancer has raised concern in most women in the United States which calls for an efficient drug to intervene (Murray, Bates & Buie, 2012). Taxane-based adjuvant chemotherapy has proven its significant benefit across the two stands of the chemotherapy, DFS and OS. A significant effect was observed during the phase III trials that involved a sample of 15, 598 patients. Taxanes were seen in DFS in large proportions with their benefits ranging from 3.3 to 4.6% on both the DFS and OS. From the various trials that were done in Phase III of the research, it was found that Taxanes provide a survival benefit more efficient compared to the standard chemotherapy (Murray, Bates & Buie, 2012).

 

References

Summerhayes, M. (2002). Capecitabine: a novel, orally administered, tumour-activated treatment for breast cancer. Journal Of Oncology Pharmacy Practice, 8(1), 1-17. doi:10.1191/1078155202jp086oa

Osamu, K., Shinya, O., Yukie, N., Shunsaku, N., Kazuaki, M., Takashi, K., & ... Manabu, M. (2015). Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression. American Journal Of Cancer Research, 5(8), 2431-2440.

Murray, B., Bates, J., & Buie, L. (2012). Impact of a new assay for measuring serum creatinine levels on carboplatin dosing. American Journal Of Health-System Pharmacy, 69(13), 1136-1141. doi:10.2146/ajhp110560