Questions and Topics We Can Help You To Answer
Paper Instructions:
Relevant info:
Experimental Yield of synthesized guaifenesin: 0.384 g
Isolated Yield of isolated guaifenesin: 0.281 g
Cough medicine tablet weighs 0.617 g
400 mg guaifenesin in each tablet
Report Instructions:
(use ChemDraw or other chemical drawing tool for creating TLC, etc in instructions)
Your Name (Alec Kain), Section 3
Title of the experiment
Title clearly identifies the research question
Results and discussion (separate sections - report results in 'results' and discuss findings/results in 'discussion')
For the discussion follow guidance from page 166. Remember to use all the concepts/keywords which are listed there: sn2 reaction mechanism, reaction yield, recovery yield, polarity and purity (TLC analysis).
In the results section present all your results. Next, in the discussion section elaborate on the meaning of these results (discuss).
Report the theoretical, obtained and recovery/isolation yields.
For synthesized guaifenesin
For isolated guaifenesin
Show your calculations in your notebook.
Report and discuss IR spectra of your products (synthesized, isolated and commercial guaifenesin) (report your data in a usual table format having complete peak analysis), draw structure of your compound on all your spectra and label all the peaks. Discuss similarities/differences between products; Compare and contrast IR spectra of synthesized, isolated and commercial guaifenesin. Identify and discuss possible impurities. Attach the original spectra at the end of your report.
Report and discuss NMR spectra of your products (synthesized, isolated and commercial guaifenesin) (report your data in a usual table format having complete peak analysis), draw structure of your compound on all of your spectra and label all the peaks. Discuss similarities/differences between products; Compare and contrast NMR spectra of synthesized, isolated and commercial guaifenesin. Identify and discuss possible impurities. Attach the original spectra at the end of your report.
Report and discuss TLC analysis your synthesized and isolated products and its comparison with commercial product. Report Rf values and discuss the results. Remember about polarity and purity concepts discussing TLC.
In your discussion consider a SN2 reaction mechanism concept.
Propose a modification of experimental procedure that would improve reaction yield. Give an example of another method of ether synthesis. Illustrate it with drawn reaction scheme; describe it in few sentences.
Conclusion(s)
In this section you summarize the main features of the report, the objectives, findings and conclusions. You briefly explain any possible sources of error relevant to your results.
References
Please cite any references in ACS format. Remember to cite every source that helped you. Only primary citation sources such as journals, books will give you a full credit.
Do not forget about proper literature citations and be aware of not committing plagiarism.
Style
Please follow ACS style guide.
