Topic: Discuss the immunopathology of Good Pastures disease and how it links to the clinical tests and treatment of the disease
Introduction
According to medical research, Goodpasture (GBM) is regarded as being one of the anti-glomerular basement membrane (GBM) ailments that affect a large percentage of individuals. The general development of the disease is based on the manner in which it results in the development and the buildup of the alpha 3(1V) collagen within the anti-glomerular basement membrane (GBM (Turner et al., 2015). Ideally, the continued development of the anti-glomerular basement membrane (GBM is what is perceived to have the propensity of resulting in the growth of glomerulonephritis as well as the malfunctioning of the human digestive system. With regard to the development of the pulmonary hemorrhage, it has been realized that hereditary angioneurotic edema is one of the diseases that are transmitted because of the general deficiency of the C esterase inhibitor (Ronco et al., 2008).
Because of such inhibition, medical research indicates that such a disease id the one that is responsible for the development of asphyxia in human beings. Regardless of the manner in which the same androgens can be used for the purpose of controlling its development, it has been realized that the fractional changes in the complexity of asthma is what might result in the development of asthma. The reason for that is because the prevailing medical research indicates that Arthus-type is ultimately enhanced by the general development of inherent allergic alveolitis (Wojnarowska & Briggaman, 1990). As a result of the continued delay and the recognition of the development of alveolitis, a person encounters various respiratory disorders. The same complexities are the one that makes the majority of the patients to have anatomic injuries.
According to the clinical information collected, it implies that the development of respiratory diseases is ultimately dependent on various mechanisms, such as collagen disease, rheumatoid pleurisies, Good-pasture syndrome, and so on. What this implies is the fact that some of the cellular reactions that occur will have to be based on individual response to immunity. In this case, the nonspecific response to certain pathogens is the one that improves or deters immune responses. As a result of that, it can be argued that Goodpasture syndrome and Goodpasture ailment refers to some of the medical constellations that leads to the development of pulmonary hemorrhage and glomerulonephritis (Parker, 2017).
On the other hand, despite its underlying pathogenesis, such a syndrome is associated with the failure of the glomerulonephritis (kidney). Such a failure is linked with the failure of the glomeruli (filtering structures). What this implies is the fact that the autoimmune syndromes that a person experiences are because of the reaction of antibodies and foreign organisms which has the likelihood of inducing pathogen concentrations (Prösch, 2003). As a result of that, symptoms that are associated with Goodpasture syndrome make a person encounter various difficulties such as chest pains, fatigue, dyspnea, (breathing difficulties), hemoptysis, anemia, and so on. Because of the malfunctioning of the kidneys, it becomes difficult for a person to excrete waste products from the kidney. This is linked with the fact that his or her kidneys will not be able to filterer blood passing through it and excrete waste products as urine. According to modern research, urinal failure is something that has been realized to affect individuals who could have been suffering from upper respiratory tract infection (Parker, 2017).
Despite that, the exact cause of this ailment is not yet known; administering plasmapheresis has been proven to counter the effects of this disease. In this procedure, there is the removal of unwanted substances, especially those that are perceived to have the propensity of effecting metabolic substances, antibodies, and so on from the circulatory system (Parker, 2017). During this process, there is the removal of blood from the patient which in return aid in the separation of blood from plasma. After that, there is the replacement of the patient’s plasma with other preserved human plasma. Before completing the whole process, the blood that was initially removed from the patient is returned or transfused to him or her (Ronco et al., 2009).
Conclusion
According to the medical explanation provided above, Goodpasture (GBM) is regarded as being one of the anti-glomerular basement membrane (GBM) ailments that will ultimately depend on the immunity of a person. What this implies is the fact that the replacement of human plasma is the one that is perceived to have the potential of improving the immunity of the patient. Because of such treatment, it is important for medical practitioners to ensure that they have understood the effectiveness of using plasmapheresis in treating such a condition (Wojnarowska & Briggaman, 1990). The reason for that is because it is the one that will enable them to understand its side effects as well as the significance of administering it with corticosteroids. Ideally, the treatment of Goodpasture ultimately depends on the immunity of a person and the effectiveness of the kidney and blood dialysis provided.
References
In Parker, G. A. (2017). Immunopathology in toxicology and drug development: Volume 2. Cham, Switzerland : Springer
In Wojnarowska, F., & In Briggaman, R. A. (1990). Management of Blistering Diseases. Boston, MA : Springer US : Imprint : Springer
Prösch, S. (2003). New aspects of CMV-related immunopathology: 4th Symposium on CMV-Related Immunopathology, Berlin, September 21-23,2002 : 7 tables. Basel: Karger.
Ronco, C., Bellomo, R., & Kellum, J. A. (2008). Critical Care Nephrology E-Book. Saunders Press
Ronco, C., Bellomo, R., & Kellum, J. A. (2009). Critical care nephrology. Philadelphia : Saunders/Elsevier
Turner, N., Lameire, N., Goldsmith, D. J., Winearls, C. G., Himmelfarb, J., & Remuzzi, G. (2015). Oxford textbook of clinical nephrology. Oxford University Press
